Details of the Target

General Information of Target

Target ID LDTP06908
Target Name Phospholipase A1 member A (PLA1A)
Gene Name PLA1A
Gene ID 51365
Synonyms
NMD; PSPLA1; Phospholipase A1 member A; EC 3.1.1.111; Phosphatidylserine-specific phospholipase A1; PS-PLA1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSN
PSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVD
WIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFG
GQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQ
DQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVT
FLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC
TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, Lipase family
Subcellular location
Secreted
Function
Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein.; [Isoform 2]: Hydrolyzes lyso-PS but not PS.
Uniprot ID
Q53H76
Ensemble ID
ENST00000273371.9
HGNC ID
HGNC:17661

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.S76C .
DU145 SNV: p.L302H .
HCT15 SNV: p.A192T .
MEWO SNV: p.P5S .
NCIH446 SNV: p.E142Ter .
RL SNV: p.P31Q .
TE4 SNV: p.Q52Ter .
TOV21G SNV: p.R198S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C420(1.20)  LDD3395  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C420(1.60)  LDD2250  [1]
 LDCM0023  KB03 A101D C420(1.81)  LDD2667  [1]
 LDCM0024  KB05 PC-3 C420(1.20)  LDD3395  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840