Details of the Target
General Information of Target
| Target ID | LDTP06888 | |||||
|---|---|---|---|---|---|---|
| Target Name | Metallophosphoesterase 1 (MPPE1) | |||||
| Gene Name | MPPE1 | |||||
| Gene ID | 65258 | |||||
| Synonyms |
PGAP5; Metallophosphoesterase 1; EC 3.1.-.-; Post-GPI attachment to proteins factor 5 |
|||||
| 3D Structure | ||||||
| Sequence |
MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASD
GEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDI FDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSS ERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLP TSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVL SGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLII YCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Metallophosphoesterase superfamily, MPPE1 family
|
|||||
| Subcellular location |
Endoplasmic reticulum-Golgi intermediate compartment membrane
|
|||||
| Function |
Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
1d-yne Probe Info |
 |
N.A. | LDD0356 | [1] | |
The Interaction Atlas With This Target