Details of the Target

General Information of Target

Target ID LDTP06871
Target Name Fibronectin type III domain-containing protein 1 (FNDC1)
Gene Name FNDC1
Gene ID 84624
Synonyms
FNDC2; KIAA1866; MEL4B3; Fibronectin type III domain-containing protein 1; Activation-associated cDNA protein; Expressed in synovial lining protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWD
PPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVS
RPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAP
RLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGR
SQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVR
YREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPT
TAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSA
LVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSP
SPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEI
TGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKP
GFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPK
GAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLS
PPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEG
AEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRG
PRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ
PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADT
EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQ
SRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD
DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR
PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV
PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR
LPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSY
RQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNP
LRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVI
KKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTT
TTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVI
YDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNK
DPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDK
ATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGP
ISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVL
CNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYR
QYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Secreted
Function May be an activator of G protein signaling.
TTD ID
T93722
Uniprot ID
Q4ZHG4
DrugMap ID
TTQJCV8
Ensemble ID
ENST00000297267.14
HGNC ID
HGNC:21184

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.V119L .
42MGBA SNV: p.E649K .
COLO800 SNV: p.P924T .
HCT116 SNV: p.P620L .
HCT15 SNV: p.C1536R .
HSC4 SNV: p.F1818L .
HT115 SNV: p.T1443N .
IGR1 SNV: p.E1563K .
IM95 SNV: p.L1429F .
IPC298 SNV: p.E545K .
JURKAT SNV: p.P1162S .
KASUMI2 Substitution: p.T438A .
KNS81FD SNV: p.R319C .
KYSE30 SNV: p.G798E .
KYSE510 SNV: p.S1163F .
MCC13 SNV: p.S625F;p.P1009S
Substitution: p.P1031L		 .
MDST8 SNV: p.E1591K .
MEWO SNV: p.P375L .
NCIH1048 Insertion: p.T1443NfsTer81 .
NCIH1793 SNV: p.R760L .
NCIH2286 SNV: p.P689H; p.R1299P .
NCIH3122 Substitution: p.G1841I .
NCIH661 SNV: p.G970V .
NUGC3 SNV: p.A1011T .
OVK18 Insertion: p.T807DfsTer60 .
RPMI8226 SNV: p.L1107F .
SH4 SNV: p.D598Y .
SHP77 SNV: p.N439K .
SKMEL2 SNV: p.E332K .
SUPT1 SNV: p.S634P; p.R1233H; p.Y1880H .
SW948 SNV: p.G792S .
T24 SNV: p.P1258S .
TE10 SNV: p.T1117K .
TFK1 Substitution: p.T438A .
THP1 SNV: p.G1737D .
TOV21G SNV: p.S1595N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TER-AC
 Probe Info  		N.A.  LDD0426  [1]

References

1 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.