Details of the Target

General Information of Target

Target ID LDTP06754
Target Name Transcription factor RFX4 (RFX4)
Gene Name RFX4
Gene ID 5992
Synonyms
Transcription factor RFX4; Regulatory factor X 4; Testis development protein NYD-SP10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHCGLLEEPDMDSTESWIERCLNESENKRYSSHTSLGNVSNDENEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLG
TRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKKEVSKQTVAYSPRSKLGTLLPE
FPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHD
LPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITK
QTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANEL
MRAMKGEGSTAEVREEIILTEAAAPTPSPVPSFSPAKSATSVEVPPPSSPVSNPSPEYTG
LSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLM
SSTPRLHPTPVTPRWPEVPSANTCYTSPSVHSARYGNSSDMYTPLTTRRNSEYEHMQHFP
GFAYINGEASTGWAK
Target Bioclass
Transcription factor
Family
RFX family
Subcellular location
Nucleus
Function
Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. May be required for neural tube ciliogenesis during embryogenesis.
Uniprot ID
Q33E94
Ensemble ID
ENST00000229387.6
HGNC ID
HGNC:9985

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R122Ter .
A172 SNV: p.S357G .
HCT15 SNV: p.A72V .
HUPT4 SNV: p.D462N .
Ishikawa (Heraklio) 02 ER Insertion: p.N49KfsTer2 .
JEKO1 SNV: p.Q139P .
KMCH1 SNV: p.E26G .
LNCaP clone FGC SNV: p.Y600C .
MFE319 SNV: p.L240P .
NCIH1703 SNV: p.G175R .
NCIH2172 SNV: p.L228I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C30(1.58)  LDD2469  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MGG123 C30(1.58)  LDD2469  [1]
 LDCM0023  KB03 MGG123 C30(1.77)  LDD2886  [1]
 LDCM0024  KB05 MGG123 C30(2.18)  LDD3303  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840