Details of the Target

General Information of Target

Target ID LDTP06742
Target Name Hereditary hemochromatosis protein (HFE)
Gene Name HFE
Gene ID 3077
Synonyms
HLAH; Hereditary hemochromatosis protein; HLA-H
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVF
YDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQV
ILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNR
AYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWL
KDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPS
PSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
Target Bioclass
Immunoglobulin
Family
MHC class I family
Subcellular location
Cell membrane
Function Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Uniprot ID
Q30201
Ensemble ID
ENST00000317896.11
HGNC ID
HGNC:4886

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.T104S .
COLO320 SNV: p.K243N .
KMRC3 SNV: p.P73S .
LNCaP clone FGC SNV: p.W94R .
TOV21G SNV: p.G139W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C61(0.93)  LDD3312  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C61(1.32)  LDD2250  [1]
 LDCM0023  KB03 A101D C61(1.70)  LDD2667  [1]
 LDCM0024  KB05 HMCB C61(0.93)  LDD3312  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-2-microglobulin (B2M) Beta-2-microglobulin family P61769

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255