Details of the Target

General Information of Target

Target ID LDTP06736
Target Name SKI family transcriptional corepressor 2 (SKOR2)
Gene Name SKOR2
Gene ID 652991
Synonyms
CORL2; FUSSEL18; SKI family transcriptional corepressor 2; Functional Smad-suppressing element on chromosome 18; Fussel-18; LBX1 corepressor 1-like protein; Ladybird homeobox corepressor 1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASSPLPGPNDILLASPSSAFQPDTLSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQE
RLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK
REAERLCKSFLGENRPPKLPDNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMY
FSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDKSPQDELVFAWEDVKAMFNGGSR
KRALPQPGAHPACHPLSSVKAAAVAAAAAVAGGGGLLGPHLLGAPPPPPPPPPPLAELAG
APHAHHKRPRFDDDDDSLQEAAVVAAASLSAAAASLSVAAASGGAGTGGGGAGGGCVAGV
GVGAGAGAGAGAGAKGPRSYPVIPVPSKGSFGGVLQKFPGCGGLFPHPYTFPAAAAAFSL
CHKKEDAGAAAEALGGAGAGGAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPPRTPGGLP
VPTYLQPPPQPPSALGCALGESPALLRQAFLDLAEPGGAAGSAEAAPPPGQPPQVVANGP
GSGPPPPAGGAGSRDALFESPPGGSGGDCSAGSTPPADSVAAAGAGAAAAGSGPAGSRVP
APHHPHLLEGRKAGGGSYHHSSAFRPVGGKDDAESLAKLHGASAGAPHSAQTHPHHHHHP
HHHHHHHHPPQPPSPLLLLPPQPDEPGSERHHPAPPPPPPPPPPPPLAQHPHHRGLLSPG
GTSCCYPSEDSSEDEDDEEEEQEVDVEGHKPPEGEEEEEGRDPDDDEEEDEETEVLLGDP
LVGGGRFLQGRGPSEKGSSRDRAPAVAGAFPLGLNSSRLLQEDGKLGDPGSDLPPPPPPP
LAPQKASGGGSSSPGSPVHHPSLEEQPSYKDSQKTKENNQVIVSTKDDNSFSDKNKEHSF
FITDSDASGGDFWRERSGEHTQETNSPHSLKKDVENMGKEELQKVLFEQIDLRRRLEQEF
QVLKGNTSFPVFNNFQDQMKRELAYREEMVQQLQIIPYAASLIRKEKLGAHLSKS
Target Bioclass
Other
Family
SKI family
Subcellular location
Nucleus
Function Exhibits transcriptional repressor activity. Acts as a TGF-beta antagonist in the nervous system.
Uniprot ID
Q2VWA4
Ensemble ID
ENST00000400404.1
HGNC ID
HGNC:32695

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R114H .
AU565 SNV: p.P545S .
DU145 SNV: p.G792W .
HCT15 SNV: p.E124D; p.R168C .
HT115 SNV: p.K73N; p.S167L; p.A1000T .
HT1376 SNV: p.S892L .
Ishikawa (Heraklio) 02 ER SNV: p.L102M .
JHH1 SNV: p.G452S .
KMS11 SNV: p.G346R .
L428 Deletion: p.T347_G353del .
MEWO SNV: p.Y176F .
MFE319 SNV: p.P183L; p.A809V .
NALM6 SNV: p.R103W .
NCIH146 SNV: p.L788I .
NCIH1792 SNV: p.G300S .
NCIH196 SNV: p.A203G .
NCIH358 SNV: p.D146Y .
OVK18 Deletion: p.P670RfsTer112
SNV: p.E432D		 .
RAMOS Insertion: p.A267_G272dup .
REH Insertion: p.A233GfsTer191 .
RKN SNV: p.A448S .
RL952 Deletion: p.K932RfsTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		D951(0.00); E948(0.00)  LDD0447  [1]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.