Details of the Target

General Information of Target

Target ID LDTP06714
Target Name Protein mono-ADP-ribosyltransferase PARP6 (PARP6)
Gene Name PARP6
Gene ID 56965
Synonyms
Protein mono-ADP-ribosyltransferase PARP6; EC 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; Poly [ADP-ribose] polymerase 6; PARP-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIRE
YGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSN
KEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPI
PKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQH
VGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSM
LKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPS
VVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQW
IISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENW
HSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYN
RMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYED
GQVGDANINTQDPKIQKEIMRVIGTQVYTN
Target Bioclass
Enzyme
Family
ARTD/PARP family
Function Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Uniprot ID
Q2NL67
Ensemble ID
ENST00000260376.11
HGNC ID
HGNC:26921
ChEMBL ID
CHEMBL2380187

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.Y539H .
COLO792 SNV: p.P251S .
HCT15 SNV: p.L236M .
JURKAT SNV: p.C584Y .
KURAMOCHI SNV: p.R381G .
RL952 SNV: p.R171Q .
TKKK SNV: p.M440I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C306(3.30)  LDD1702  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C306(3.30)  LDD1702  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761