Details of the Target
General Information of Target
| Target ID | LDTP06682 | |||||
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| Target Name | MHC class I polypeptide-related sequence B (MICB) |
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| Gene Name | MICB | |||||
| Gene ID | 4277 | |||||
| Synonyms |
PERB11.2; MHC class I polypeptide-related sequence B; MIC-B |
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| 3D Structure | ||||||
| Sequence |
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYD
RQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCE IHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHY RAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWR QDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKA LVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHR DAAQLGFQPLMSATGSTGSTEGT |
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| Target Bioclass |
Immunoglobulin
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| Family |
MHC class I family, MIC subfamily
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| Subcellular location |
Cell membrane
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| Function |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STPyne Probe Info |
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K196(7.14) | LDD0277 | [1] | |
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OPA-S-S-alkyne Probe Info |
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K190(1.17); K196(4.62) | LDD3494 | [2] | |
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DBIA Probe Info |
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C187(7.73) | LDD3392 | [3] | |
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IA-alkyne Probe Info |
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N.A. | LDD0175 | [4] | |
Competitor(s) Related to This Target
References