Details of the Target
General Information of Target
| Target ID | LDTP06680 | |||||
|---|---|---|---|---|---|---|
| Target Name | Transmembrane protein 132A (TMEM132A) | |||||
| Gene Name | TMEM132A | |||||
| Gene ID | 54972 | |||||
| Synonyms |
HSPA5BP1; KIAA1583; Transmembrane protein 132A; HSPA5-binding protein 1 |
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| 3D Structure | ||||||
| Sequence |
MCARMAGRTTAAPRGPYGPWLCLLVALALDVVRVDCGQAPLDPVYLPAALELLDAPEHFR
VQQVGHYPPANSSLSSRSETFLLLQPWPRAQPLLRASYPPFATQQVVPPRVTEPHQRPVP WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGSLPCARLHATHPAGTAHQACRFQPS LGACVVELELPSHWFSQASTTRAELAYTLEPAAEGPGGCGSGEENDPGEQALPVGGVELR PADPPQYQEVPLDEAVTLRVPDMPVRPGQLFSATLLLRHNFTASLLTLRIKVKKGLHVTA ARPAQPTLWTAKLDRFKGSRHHTTLITCHRAGLTEPDSSPLELSEFLWVDFVVENSTGGG VAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQH VPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGARGVRVDFWWR RLRASLRLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAEGPAEPAAEASDEAERRARGCH LQYQRAGVRFLAPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAPHARVLDSRVASLEGGRV VVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVMGISLTLSRGTAHPGE VTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEEQ GAQLGVVVSGAGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPASTPAPALPSSP AWSPPATEATMGGKRQVAGSVGGNTGVRGKFERAEEEARKEETEAREEEEEEEEEMVPAP QHVTELELGMYALLGVFCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTSPQPHNWVWLGT DQEELSRQLDRQSPGPPKGEGSCPCESGGGGEAPTLAPGPPGGTTSSSSTLARKEAGGRR KRVEFVTFAPAPPAQSPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIR GSS |
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| Target Bioclass |
Transporter and channel
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| Family |
TMEM132 family
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| Subcellular location |
Golgi apparatus membrane
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| Function |
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| HT115 | SNV: p.P422L | . | |||
| TOV21G | SNV: p.P216H | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
OPA-S-S-alkyne Probe Info |
 |
K820(2.34) | LDD3494 | [1] | |
|
DBIA Probe Info |
 |
C752(2.68) | LDD3312 | [2] | |
|
BTD Probe Info |
 |
C539(0.97) | LDD2117 | [3] | |
|
Acrolein Probe Info |
 |
H172(0.00); C175(0.00); C1001(0.00) | LDD0222 | [4] | |
|
JW-RF-010 Probe Info |
 |
C923(0.00); C925(0.00) | LDD0026 | [5] | |
|
TFBX Probe Info |
 |
C925(0.00); C923(0.00) | LDD0027 | [5] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2223 | [6] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C539(0.97) | LDD2117 | [3] |
| LDCM0108 | Chloroacetamide | HeLa | H172(0.00); C175(0.00); C1001(0.00) | LDD0222 | [4] |
| LDCM0022 | KB02 | HEK-293T | C1001(1.02) | LDD1492 | [7] |
| LDCM0023 | KB03 | HEK-293T | C1001(0.91) | LDD1497 | [7] |
| LDCM0024 | KB05 | HMCB | C752(2.68) | LDD3312 | [2] |
| LDCM0109 | NEM | HeLa | N.A. | LDD0223 | [4] |
References