Details of the Target

General Information of Target

Target ID LDTP06679
Target Name Protein FAM110C (FAM110C)
Gene Name FAM110C
Gene ID 642273
Synonyms
Protein FAM110C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRALAALSAPPNERLLPRDPAATRDPDAARPARRSAVERLAADRAKYVRGRPGTGRGVAS
EGSGPGAIKCPGNDPGPPARAPAPVARRAIARKPLRPDSLIIYRQKCEFVRGSGADGPRA
SLVKKLFQGPGKDKAPVPRTGDEGKAGNPETVPTTPGPAADPAIPETPAPAARSAAPSSV
PAAPPGPEPRVVRRRGLQRSQSDLSSRYSAALAESDTFFQYCGLDPEVVEALGRENFTAG
SDCVTLKVRSVSVATSGSGFSRHSGGDDEGLQEEELIEQVPSTTSVIERNARIIKWLYTC
KKAKETPSQEQSRTRGSKPSR
Target Bioclass
Other
Family
FAM110 family
Subcellular location
Cytoplasm, cytoskeleton
Function May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.
Uniprot ID
Q1W6H9
Ensemble ID
ENST00000327669.5
HGNC ID
HGNC:33340

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C300(18.04)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AN3-CA C300(2.12)  LDD2264  [2]
 LDCM0023  KB03 Jurkat C300(18.04)  LDD0209  [1]
 LDCM0024  KB05 Hs 936.T C70(1.39)  LDD3313  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Casein kinase I isoform epsilon (CSNK1E) CK1 Ser/Thr protein kinase family P49674

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840