Details of the Target

General Information of Target

Target ID LDTP06671
Target Name Endothelial cell-specific chemotaxis regulator (ECSCR)
Gene Name ECSCR
Gene ID 641700
Synonyms
ECSM2; Endothelial cell-specific chemotaxis regulator; Apoptosis regulator through modulating IAP expression; ARIA; Endothelial cell-specific molecule 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEA
NRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVL
TVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKD
SITLISMKNINMNNGKQSLSAEKVL
Target Bioclass
Other
Family
ECSCR family
Subcellular location
Cell membrane
Function
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.
Uniprot ID
Q19T08
Ensemble ID
ENST00000618155.3
HGNC ID
HGNC:35454

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C172(1.47)  LDD3478  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 TYK-nu C172(1.09)  LDD2644  [1]
 LDCM0023  KB03 TYK-nu C172(1.24)  LDD3061  [1]
 LDCM0024  KB05 TYK-nu C172(1.47)  LDD3478  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840