Details of the Target

General Information of Target

Target ID LDTP06661
Target Name Interphotoreceptor matrix proteoglycan 1 (IMPG1)
Gene Name IMPG1
Gene ID 3617
Synonyms
IPM150; SPACR; Interphotoreceptor matrix proteoglycan 1; Interphotoreceptor matrix proteoglycan of 150 kDa; IPM-150; Sialoprotein associated with cones and rods
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYLETRRAIFVFWIFLQVQGTKDISINIYHSETKDIDNPPRNETTESTEKMYKMSTMRRI
FDLAKHRTKRSAFFPTGVKVCPQESMKQILDSLQAYYRLRVCQEAVWEAYRIFLDRIPDT
GEYQDWVSICQQETFCLFDIGKNFSNSQEHLDLLQQRIKQRSFPDRKDEISAEKTLGEPG
ETIVISTDVANVSLGPFPLTPDDTLLNEILDNTLNDTKMPTTERETEFAVLEEQRVELSV
SLVNQKFKAELADSQSPYYQELAGKSQLQMQKIFKKLPGFKKIHVLGFRPKKEKDGSSST
EMQLTAIFKRHSAEAKSPASDLLSFDSNKIESEEVYHGTMEEDKQPEIYLTATDLKRLIS
KALEEEQSLDVGTIQFTDEIAGSLPAFGPDTQSELPTSFAVITEDATLSPELPPVEPQLE
TVDGAEHGLPDTSWSPPAMASTSLSEAPPFFMASSIFSLTDQGTTDTMATDQTMLVPGLT
IPTSDYSAISQLALGISHPPASSDDSRSSAGGEDMVRHLDEMDLSDTPAPSEVPELSEYV
SVPDHFLEDTTPVSALQYITTSSMTIAPKGRELVVFFSLRVANMAFSNDLFNKSSLEYRA
LEQQFTQLLVPYLRSNLTGFKQLEILNFRNGSVIVNSKMKFAKSVPYNLTKAVHGVLEDF
RSAAAQQLHLEIDSYSLNIEPADQADPCKFLACGEFAQCVKNERTEEAECRCKPGYDSQG
SLDGLEPGLCGPGTKECEVLQGKGAPCRLPDHSENQAYKTSVKKFQNQQNNKVISKRNSE
LLTVEYEEFNHQDWEGN
Target Bioclass
Other
Subcellular location
Cell projection, cilium, photoreceptor outer segment
Function Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.
Uniprot ID
Q17R60
Ensemble ID
ENST00000369950.8
HGNC ID
HGNC:6055

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.R224K .
GB1 SNV: p.D751E .
HCC15 SNV: p.E394V .
IGROV1 Deletion: p.W13GfsTer24 .
Ishikawa (Heraklio) 02 ER SNV: p.H752R .
KMCH1 Substitution: p.S443F .
KYSE150 SNV: p.E597K .
MCC13 SNV: p.G264E .
MEWO SNV: p.L16F .
NB1 SNV: p.N215K .
NCIH23 SNV: p.C81Ter .
NCIH661 SNV: p.P290Q .
OVCAR4 SNV: p.S31P .
SNGM SNV: p.P290S .
SW1271 SNV: p.E364Ter .
TOV21G Deletion: p.K764SfsTer10 .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [1]

References

1 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.