Details of the Target

General Information of Target

Target ID LDTP06637
Target Name Protein phosphatase 1 regulatory subunit 3A (PPP1R3A)
Gene Name PPP1R3A
Gene ID 5506
Synonyms
PP1G; Protein phosphatase 1 regulatory subunit 3A; Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase type-1 glycogen targeting subunit; RG1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPSEVPSQISKDNFLEVPNLSDSLCEDEEVTFQPGFSPQPSRRGSDSSEDIYLDTPSSG
TRRVSFADSFGFNLVSVKEFDCWELPSASTTFDLGTDIFHTEEYVLAPLFDLPSSKEDLM
QQLQIQKAILESTESLLGSTSIKGIIRVLNVSFEKLVYVRMSLDDWQTHYDILAEYVPNS
CDGETDQFSFKIVLVPPYQKDGSKVEFCIRYETSVGTFWSNNNGTNYTFICQKKEQEPEP
VKPWKEVPNRQIKGCLKVKSSKEESSVTSEENNFENPKNTDTYIPTIICSHEDKEDLEAS
NRNVKDVNREHDEHNEKELELMINQHLIRTRSTASRDERNTFSTDPVNFPNKAEGLEKKQ
IHGEICTDLFQRSLSPSSSAESSVKGDFYCNEKYSSGDDCTHQPSEETTSNMGEIKPSLG
DTSSDELVQLHTGSKEVLDDNANPAHGNGTVQIPCPSSDQLMAGNLNKKHEGGAKNIEVK
DLGCLRRDFHSDTSACLKESTEEGSSKEDYYGNGKDDEEQRIYLGVNEKQRKNFQTILHD
QERKMGNPKISVAGIGASNRDLATLLSEHTAIPTRAITADVSHSPRTNLSWEEAVLTPEH
HHLTSEGSALGGITGQVCSSRTGNVLRNDYLFQVEEKSGGINSEDQDNSPQHKQSWNVLE
SQGKSRENKTNITEHIKGQTDCEDVWGKRDNTRSLKATTEELFTCQETVCCELSSLADHG
ITEKAEAGTAYIIKTTSESTPESMSAREKAIIAKLPQETARSDRPIEVKETAFDPHEGRN
DDSHYTLCQRDTVGVIYDNDFEKESRLGICNVRVDEMEKEETMSMYNPRKTHDREKCGTG
NITSVEESSWVITEYQKATSKLDLQLGMLPTDKTVFSENRDLRQVQELSKKTDSDAIVHS
AFNSDTNRAPQNSSPFSKHHTEISVSTNEQAIAVENAVTTMASQPISTKSENICNSTREI
QGIEKHPYPESKPEEVSRSSGIVTSGSRKERCIGQIFQTEEYSVEKSLGPMILINKPLEN
MEEARHENEGLVSSGQSLYTSGEKESDSSASTSLPVEESQAQGNESLFSKYTNSKIPYFL
LFLIFLITVYHYDLMIGLTFYVLSLSWLSWEEGRQKESVKKK
Target Bioclass
Other
Subcellular location
Membrane
Function
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
Uniprot ID
Q16821
Ensemble ID
ENST00000284601.4
HGNC ID
HGNC:9291

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A571T .
COLO678 SNV: p.G728V; p.K1044Ter .
DANG SNV: p.W686L .
G415 SNV: p.E392D .
HCC1143 SNV: p.G554A .
HT115 SNV: p.H899R; p.P910T; p.N1073T .
IPC298 SNV: p.G1030E .
Ishikawa (Heraklio) 02 ER SNV: p.L54M .
KYSE150 SNV: p.L356F .
LNCaP clone FGC SNV: p.I209M .
MCC13 SNV: p.W83Ter; p.E392K .
MDAMB453 SNV: p.R689K .
MDST8 SNV: p.G663E .
MELJUSO SNV: p.E271D .
MEWO SNV: p.G981E .
MKN1 SNV: p.P741Q .
NCIH2172 SNV: p.L1054I .
OVK18 SNV: p.I365M .
RKN SNV: p.D718N .
SCC25 SNV: p.F876L .
SKHEP1 SNV: p.A1024V .
SKMEL28 SNV: p.E528K .
SKOV3 SNV: p.F229L .
SNGM SNV: p.S649G; p.Y785H .
SW948 SNV: p.T408A .
TE1 SNV: p.E407K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C289(1.95)  LDD3364  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C954(0.97)  LDD2263  [1]
 LDCM0023  KB03 HGC-27 C810(2.12); C289(1.42); C954(2.06)  LDD2773  [1]
 LDCM0024  KB05 NCI-N87 C289(1.95)  LDD3364  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840