Details of the Target
General Information of Target
| Target ID | LDTP06632 | |||||
|---|---|---|---|---|---|---|
| Target Name | NADP-dependent malic enzyme, mitochondrial (ME3) | |||||
| Gene Name | ME3 | |||||
| Gene ID | 10873 | |||||
| Synonyms |
NADP-dependent malic enzyme, mitochondrial; NADP-ME; EC 1.1.1.40; Malic enzyme 3 |
|||||
| 3D Structure | ||||||
| Sequence |
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN VQTV |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Malic enzymes family
|
|||||
| Subcellular location |
Mitochondrion matrix
|
|||||
| Function | Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor. Can also reverse the decarboxylation reaction, but only with significantly lower efficiency. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| AN3CA | SNV: p.K354R | . | |||
| CCK81 | SNV: p.L150P | DBIA Probe Info | |||
| HCC15 | Deletion: p.E98RfsTer11 | DBIA Probe Info | |||
| HCT15 | SNV: p.C275Y | DBIA Probe Info | |||
| HT115 | SNV: p.S545F | . | |||
| IGR1 | SNV: p.W25Ter | . | |||
| MCAS | SNV: p.G166D | . | |||
| MELJUSO | SNV: p.S431F | . | |||
| NCIH3122 | SNV: p.P13L | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C145(0.90); C199(1.57) | LDD3310 | [1] | |
Competitor(s) Related to This Target