Details of the Target

General Information of Target

Target ID LDTP06610
Target Name Histone H3.1t (H3-4)
Gene Name H3-4
Gene ID 8290
Synonyms
H3FT; HIST3H3; Histone H3.1t; H3/t; H3t; H3/g; Histone H3.4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLMREIAQDFKTDLRFQSSAVMALQEACESYLVGLFEDTNLCVIHAKRVTI
MPKDIQLARRIRGERA
Target Bioclass
Other
Family
Histone H3 family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q16695
Ensemble ID
ENST00000366696.2
HGNC ID
HGNC:4778

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.53  LDD0402  [1]
AZ-9
 Probe Info  		D78(0.98)  LDD2208  [2]
Acrolein
 Probe Info  		K123(0.00); K57(0.00)  LDD0221  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
STPyne
 Probe Info  		K37(0.00); K80(0.00); K57(0.00); K123(0.00)  LDD0009  [5]
AOyne
 Probe Info  		13.60  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa K57(0.00); K123(0.00)  LDD0222  [3]
 LDCM0107  IAA HeLa K123(0.00); K57(0.00)  LDD0221  [3]
 LDCM0109  NEM HeLa K57(0.00); K80(0.00)  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Lysine-specific demethylase 4A (KDM4A) JHDM3 histone demethylase family O75164
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2A type 1-B/E (H2AC4; H2AC8) Histone H2A family P04908
Histone H2AX (H2AX) Histone H2A family P16104
Histone H3.2 (H3C15; H3C14; H3C13) Histone H3 family Q71DI3
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Protein ripply1 (RIPPLY1) Ripply family Q0D2K3
Chromobox protein homolog 5 (CBX5) . P45973
Scm-like with four MBT domains protein 1 (SFMBT1) . Q9UHJ3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.