Details of the Target

General Information of Target

Target ID LDTP06605
Target Name Anti-Muellerian hormone type-2 receptor (AMHR2)
Gene Name AMHR2
Gene ID 269
Synonyms
AMHR; MISR2; Anti-Muellerian hormone type-2 receptor; EC 2.7.11.30; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRC
CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY
SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGE
PVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQF
QAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGS
SLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPG
LTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEI
LSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGL
RELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPT
ILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Subcellular location
Membrane
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
TTD ID
T36440
Uniprot ID
Q16671
DrugMap ID
TTZDCPK
Ensemble ID
ENST00000257863.9
HGNC ID
HGNC:465

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.C487G .
COLO678 SNV: p.Y57S .
HCT15 SNV: p.G142C .
ICC12 SNV: p.P96L .
IGR1 SNV: p.L43I .
LOXIMVI SNV: p.S273F .
MCC13 SNV: p.G224E .
MFE319 SNV: p.G311A .
MOLT4 SNV: p.S89F .
NCIH1155 SNV: p.P389L .
OCUM1 SNV: p.S194R .
RL952 SNV: p.L156F .
TE4 SNV: p.S194R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPIAA_H
 Probe Info  		N.A.  LDD0030  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Myelin and lymphocyte protein (MAL) MAL family P21145

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171

References

1 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647