General Information of Target

Target ID LDTP06594
Target Name Myelin-oligodendrocyte glycoprotein (MOG)
Gene Name MOG
Gene ID 4340
Synonyms
Myelin-oligodendrocyte glycoprotein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLSRPSLPSCLCSFLLLLLLQVSSSYAGQFRVIGPRHPIRALVGDEVELPCRISPGKN
ATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRFS
DEGGFTCFFRDHSYQEEAAMELKVEDPFYWVSPGVLVLLAVLPVLLLQITVGLIFLCLQY
RLRGKLRAEIENLHRTFDPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLAGQFL
EELRNPF
Target Type
Literature-reported
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, BTN/MOG family
Subcellular location
Cell membrane
Function
Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.; (Microbial infection) Acts as a receptor for rubella virus.
TTD ID
T00295
Uniprot ID
Q16653
DrugMap ID
TTQAFX5
Ensemble ID
ENST00000259891.11
HGNC ID
HGNC:7197

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 SNV: p.Q23R .
MDST8 SNV: p.P147S .
NALM6 SNV: p.L166I .
NCIH1666 SNV: p.C206Ter .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info 
N.A.  LDD0138  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84

References

1 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.