Details of the Target

General Information of Target

Target ID LDTP06567
Target Name Zinc finger protein 74 (ZNF74)
Gene Name ZNF74
Gene ID 7625
Synonyms
ZNF520; Zinc finger protein 74; Zinc finger protein 520; hZNF7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIPAPEPEKTALSSQDPALSLKENLEDISGWGLPEARSKESVSFKDVAVDFTQEEWGQL
DSPQRALYRDVMLENYQNLLALGPPLHKPDVISHLERGEEPWSMQREVPRGPCPEWELKA
VPSQQQGICKEEPAQEPIMERPLGGAQAWGRQAGALQRSQAAPWAPAPAMVWDVPVEEFP
LRCPLFAQQRVPEGGPLLDTRKNVQATEGRTKAPARLCAGENASTPSEPEKFPQVRRQRG
AGAGEGEFVCGECGKAFRQSSSLTLHRRWHSREKAYKCDECGKAFTWSTNLLEHRRIHTG
EKPFFCGECGKAFSCHSSLNVHQRIHTGERPYKCSACEKAFSCSSLLSMHLRVHTGEKPY
RCGECGKAFNQRTHLTRHHRIHTGEKPYQCGSCGKAFTCHSSLTVHEKIHSGDKPFKCSD
CEKAFNSRSRLTLHQRTHTGEKPFKCADCGKGFSCHAYLLVHRRIHSGEKPFKCNECGKA
FSSHAYLIVHRRIHTGEKPFDCSQCWKAFSCHSSLIVHQRIHTGEKPYKCSECGRAFSQN
HCLIKHQKIHSGEKSFKCEKCGEMFNWSSHLTEHQRLHSEGKPLAIQFNKHLLSTYYVPG
SLLGAGDAGLRDVDPIDALDVAKLLCVVPPRAGRNFSLGSKPRN
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May play a role in RNA metabolism.
Uniprot ID
Q16587
Ensemble ID
ENST00000400451.7
HGNC ID
HGNC:13144

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.W32L; p.P35A .
EFO21 SNV: p.R372S .
HCC1419 Substitution: p.Y597N .
Ishikawa (Heraklio) 02 ER SNV: p.E208D .
NCIH1993 Substitution: p.Y597N .
OPM2 SNV: p.E407A .
SNU1 SNV: p.R352W .
SUPT1 SNV: p.P229L .
TF1 SNV: p.G391R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C97(1.53); C183(1.46); C42(1.70)  LDD3368  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
HHS-465
 Probe Info  		K526(0.00); K529(0.00); Y528(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C97(1.40); C183(1.46); C42(2.15)  LDD2254  [1]
 LDCM0023  KB03 A2780 C97(1.30); C42(1.55); C218(1.60)  LDD2671  [1]
 LDCM0024  KB05 OAW-28 C97(1.53); C183(1.46); C42(1.70)  LDD3368  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010