Details of the Target

General Information of Target

Target ID LDTP06559
Target Name Cocaine- and amphetamine-regulated transcript protein (CARTPT)
Gene Name CARTPT
Gene ID 9607
Synonyms
CART; Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39; CART(42-89)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAVDDASHEKELIEALQEV
LKKLKSKRVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL
Target Bioclass
Other
Family
CART family
Subcellular location
Secreted
Function
Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
Uniprot ID
Q16568
Ensemble ID
ENST00000296777.5
HGNC ID
HGNC:24323

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C82(1.92)  LDD2157  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) CEA family P13688
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amphetamine Small molecular drug DB00182

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151