Details of the Target

General Information of Target

Target ID LDTP06530
Target Name Protein SSX2 (SSX2; SSX2B)
Gene Name SSX2; SSX2B
Gene ID 6757
Synonyms
SSX2A; Protein SSX2; Cancer/testis antigen 5.2; CT5.2; Synovial sarcoma, X breakpoint 2; Tumor antigen HOM-MEL-40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASEKIFYVYMKRKYEAMTK
LGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFGRLQGISPKIMPKKPAEEG
NDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGPKRGEHAWTHRLRERKQLVIYEEI
SDPEEDDE
Target Bioclass
Other
Family
SSX family
Subcellular location
Nucleus
Function Could act as a modulator of transcription.
Uniprot ID
Q16385
Ensemble ID
ENST00000336777.9
HGNC ID
HGNC:11336

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C140(1.89)  LDD3351  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C72(1.71); C140(1.22)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C72(1.55); C140(1.09)  LDD2660  [1]
 LDCM0024  KB05 NCI-H196 C140(1.89)  LDD3351  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840