Details of the Target

General Information of Target

Target ID LDTP06520
Target Name Insulin-like growth factor-binding protein 7 (IGFBP7)
Gene Name IGFBP7
Gene ID 3490
Synonyms
MAC25; PSF; Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCC
PMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVC
GSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLS
CEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSK
EDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL
Target Type
Literature-reported
Target Bioclass
Immunoglobulin
Subcellular location
Secreted
Function Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
TTD ID
T69271
Uniprot ID
Q16270
DrugMap ID
TTUQ01B
Ensemble ID
ENST00000295666.6
HGNC ID
HGNC:5476

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A147V .
MDAMB436 Insertion: p.R7_A8insFSCFGVPEE .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K114(2.98); K275(10.00); K89(3.70)  LDD0277  [1]
IPM
 Probe Info  		C113(0.98)  LDD1701  [2]
DBIA
 Probe Info  		C120(0.99); C131(0.99); C111(0.94); C113(0.94)  LDD0078  [3]
m-APA
 Probe Info  		H249(0.00); H270(0.00)  LDD2231  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		C113(0.00); C131(0.00); C111(0.00)  LDD0027  [6]
Acrolein
 Probe Info  		C248(0.00); C71(0.00)  LDD0217  [7]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
Methacrolein
 Probe Info  		C248(0.00); C71(0.00); C81(0.00); C120(0.00)  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C120(0.99); C131(0.99); C111(0.94); C113(0.94)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C111(1.11); C113(0.77)  LDD1702  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 769-P C71(1.64)  LDD2246  [8]
 LDCM0023  KB03 MDA-MB-231 C113(0.98)  LDD1701  [2]
 LDCM0024  KB05 MEL167 C248(2.92)  LDD3316  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Insulin Human BiotechDrug DB00030

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840