Details of the Target

General Information of Target

Target ID LDTP06512
Target Name Beta-synuclein (SNCB)
Gene Name SNCB
Gene ID 6620
Synonyms
Beta-synuclein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK
EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE
DPPQEEYQEYEPEA
Target Bioclass
Transporter and channel
Family
Synuclein family
Subcellular location
Cytoplasm
Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Uniprot ID
Q16143
Ensemble ID
ENST00000310112.7
HGNC ID
HGNC:11140

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y39(0.97)  LDD0264  [1]
HHS-465
 Probe Info  		Y39(0.00); K43(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y39(0.97)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y39(0.89)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y39(0.73)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y39(0.96)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y39(0.93)  LDD0268  [1]

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010