Details of the Target

General Information of Target

Target ID LDTP06498
Target Name Endosomal transmembrane epsin interactor 1 (ENTREP1)
Gene Name ENTREP1
Gene ID 9413
Synonyms
C9orf61; FAM189A2; X123; Endosomal transmembrane epsin interactor 1; Endosomal transmembrane binding with epsin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAK
CTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFATRRSCI
DESQISAEEAEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGA
RIKGVEVFCPLDPPPPYEAVVSQMDQEQGSSFQMSEGSEAAVIPLDLGCTQVTQDGDIPN
IPAEENASTSTPSSTLVRPIRSRRALPPLRTRSKSDPVLHPSEERAAPVLSCEAATQTER
RLDLAAVTLRRGLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENI
KSVLKSDEEHMEEAITSASFLEQIMAPLQPSTSRAHKLPSRRQPGLLHLQSCGDLHTFTP
AGRPRAERRPRRVEAERPHSLIGVIRETVL
Target Bioclass
Other
Family
ENTREP family
Subcellular location
Early endosome membrane
Function
Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway.
Uniprot ID
Q15884
Ensemble ID
ENST00000257515.12
HGNC ID
HGNC:24820

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C292(1.07)  LDD1571  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C292(1.07)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C292(0.91)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C292(0.84)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C292(0.99)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C292(1.01)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C292(0.91)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C292(0.91)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C292(0.95)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C292(0.90)  LDD1604  [1]
 LDCM0413  CL25 HEK-293T C292(0.80)  LDD1617  [1]
 LDCM0426  CL37 HEK-293T C292(0.81)  LDD1630  [1]
 LDCM0439  CL49 HEK-293T C292(0.93)  LDD1643  [1]
 LDCM0453  CL61 HEK-293T C292(1.03)  LDD1656  [1]
 LDCM0466  CL73 HEK-293T C292(1.04)  LDD1669  [1]
 LDCM0479  CL85 HEK-293T C292(0.77)  LDD1682  [1]
 LDCM0492  CL97 HEK-293T C292(1.02)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264