Details of the Target

General Information of Target

Target ID LDTP06496
Target Name Sodium channel protein type 9 subunit alpha (SCN9A)
Gene Name SCN9A
Gene ID 6335
Synonyms
NENA; Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP
FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI
KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE
FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR
KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ
DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE
LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRR
KKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIR
GSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS
NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEVIIDKATSDDSGT
TNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHK
FLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGN
LVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLL
RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIN
DDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVL
NLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKI
SREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFI
HNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEE
AEAEPMNSDEPEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVL
MILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCW
LDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPS
IMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNV
RWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVF
IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP
GNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTG
ECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRI
LRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFN
FETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYF
VSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFS
KLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLR
SQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDG
DRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKG
KDSKESKK
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Sodium channel (TC 1.A.1.10) family, Nav1.7/SCN9A subfamily
Subcellular location
Cell membrane
Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
TTD ID
T12119
Uniprot ID
Q15858
DrugMap ID
TT4G2JS
Ensemble ID
ENST00000303354.11
HGNC ID
HGNC:10597
ChEMBL ID
CHEMBL4296

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.L967S .
A2780 SNV: p.L1467F .
A375 SNV: p.S970Ter .
AU565 SNV: p.E937K .
BICR22 SNV: p.F1679L .
CASKI SNV: p.S1192C .
CCK81 Deletion: p.T96QfsTer20 .
CCSW1 SNV: p.R117S .
COLO792 SNV: p.M268L .
COLO800 SNV: p.S466F .
G361 SNV: p.D1729H .
HCC1954 SNV: p.D1057E .
HCT116 SNV: p.T1632M .
HCT15 SNV: p.N282K; p.G1407R .
HEC1 SNV: p.V1376D .
HSC3 Deletion: p.K1220RfsTer24 .
HT115 SNV: p.R1367C .
IGROV1 SNV: p.I1746M .
IPC298 SNV: p.S1873F
Substitution: p.G491K		 .
Ishikawa (Heraklio) 02 ER SNV: p.T1632M .
JURKAT SNV: p.A1414V .
KMCH1 SNV: p.V90I .
MCC26 SNV: p.E1144K .
MDST8 SNV: p.P1319S .
MEWO SNV: p.P1811S .
MFE319 Deletion: p.V1720FfsTer33
SNV: p.L53V		 .
MIAPACA2 SNV: p.E1369K .
NCIH2172 SNV: p.R540L; p.N1908I .
NCIH2291 SNV: p.G1833S .
NCIH716 Deletion: p.K1988NfsTer20 .
NUGC3 SNV: p.I1224T; p.W1258C .
OE33 SNV: p.R1619Q .
P31FUJ SNV: p.R1022G .
PANC1 SNV: p.T1696I .
RKO SNV: p.S1123C .
SKN SNV: p.A437V .
SNGM SNV: p.S862A; p.K1019T .
SNU1196 SNV: p.D1923N .
SUPT1 SNV: p.S706F .
SW403 SNV: p.V828M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264