Details of the Target

General Information of Target

Target ID LDTP06470
Target Name Metallophosphoesterase MPPED2 (MPPED2)
Gene Name MPPED2
Gene ID 744
Synonyms
C11orf8; FAM1B; Metallophosphoesterase MPPED2; EC 3.1.-.-; Fetal brain protein 239; 239FB; Metallophosphoesterase domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMVDPIPYDTPKPAGHTRF
VCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDWLGNLPYEYKIVIAGNHEL
TFDKEFMADLVKQDYYRFPSVSKLKPEDFDNVQSLLTNSIYLQDSEVTVKGFRIYGAPWT
PWFNGWGFNLPRGQSLLDKWNLIPEGIDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQ
RRVRPKLHVFGGIHEGYGIMTDGYTTYINASTCTVSFQPTNPPIIFDLPNPQGS
Target Bioclass
Enzyme
Family
UPF0046 family
Function Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.
Uniprot ID
Q15777
Ensemble ID
ENST00000358117.10
HGNC ID
HGNC:1180

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 SNV: p.L81F .
DU145 SNV: p.A2V .
HEC1 SNV: p.G85C .
HLF SNV: p.K143N .
NCIH23 SNV: p.R35I .
RKO SNV: p.Y49H .
SKMEL28 SNV: p.R229S .
TE11 SNV: p.E147G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0230  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore complex protein Nup93 (NUP93) Nucleoporin interacting component (NIC) family Q8N1F7
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoic acid receptor RXR-gamma (RXRG) Nuclear hormone receptor family P48443
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX4 (BEX4) BEX family Q9NWD9
Protein FAM72A (FAM72A) FAM72 family Q5TYM5
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Proteasome maturation protein (POMP) POMP/UMP1 family Q9Y244
RIB43A-like with coiled-coils protein 1 (RIBC1) RIB43A family Q8N443
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Cancer-associated gene 1 protein (CAGE1) . Q8TC20

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.