Details of the Target

General Information of Target

Target ID LDTP06458
Target Name CCAAT/enhancer-binding protein epsilon (CEBPE)
Gene Name CEBPE
Gene ID 1053
Synonyms
CCAAT/enhancer-binding protein epsilon; C/EBP epsilon
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIESGEEQLLSDLFAV
KPAPEARGLKGPGTPAFPHYLPPDPRPFAYPPHTFGPDRKALGPGIYSSPGSYDPRAVAV
KEEPRGPEGSRAASRGSYNPLQYQVAHCGQTAMHLPPTLAAPGQPLRVLKAPLATAAPPC
SPLLKAPSPAGPLHKGKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRILETQQKVLEYM
AENERLRSRVEQLTQELDTLRNLFRQIPEAANLIKGVGGCS
Target Bioclass
Transcription factor
Family
BZIP family, C/EBP subfamily
Subcellular location
Nucleus
Function
Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.
Uniprot ID
Q15744
Ensemble ID
ENST00000206513.6
HGNC ID
HGNC:1836

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0032  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) BZIP family Q9NR55
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
DNA damage-inducible transcript 3 protein (DDIT3) BZIP family P35638
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
CCAAT/enhancer-binding protein alpha (CEBPA) BZIP family P49715
CCAAT/enhancer-binding protein gamma (CEBPG) BZIP family P53567

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060