Details of the Target

General Information of Target

Target ID LDTP06258
Target Name Calcium-activated chloride channel regulator 4 (CLCA4)
Gene Name CLCA4
Gene ID 22802
Synonyms
CaCC2; Calcium-activated chloride channel regulator 4; EC 3.4.-.-; Calcium-activated chloride channel family member 4; hCLCA4; Calcium-activated chloride channel protein 2; CaCC-2; hCaCC-2; Chloride channel accessory 4) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTAS
TYLFEATEKRFFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQ
FTECGEKGEYIHFTPDLLLGKKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSK
KIEATRCSAGISGRNRVYKCQGGSCLSRACRIDSTTKLYGKDCQFFPDKVQTEKASIMFM
QSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSEDFKNTIPMVTPPPPPVFSLL
KISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFDSTATIVNKLI
QIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTAS
SCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGN
TDLSQKSLQLESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIM
ENFTVDATSKMAYLSIPGTAKVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKM
NKDVNSFPSPMIVYAEILQGYVPVLGANVTAFIESQNGHTEVLELLDNGAGADSFKNDGV
YSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAYIPGWVVNGEIEANPPRPEID
EDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKIILTWTAPGDN
FDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATH
IFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTL
VLSVIGSVVIVNFILSTTI
Target Bioclass
Enzyme
Family
CLCR family
Subcellular location
Cell membrane
Function May be involved in mediating calcium-activated chloride conductance.
Uniprot ID
Q14CN2
Ensemble ID
ENST00000370563.3
HGNC ID
HGNC:2018
ChEMBL ID
CHEMBL2364708

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.L399I .
A3KAW SNV: p.D516G .
A549 SNV: p.D443A .
DU145 SNV: p.S271G .
HT1080 SNV: p.I612M .
HT115 SNV: p.A235S .
LNCaP clone FGC SNV: p.D222Y .
NB1 SNV: p.Q257Ter .
NCIH1666 SNV: p.P149Q .
OAW42 SNV: p.V103I .
OVISE SNV: p.P575T .
SAOS2 Deletion: p.T878LfsTer26 .
SKMEL24 SNV: p.G620R .
SNU1196 SNV: p.L798P .
VCAP SNV: p.E709G .
YSCCC SNV: p.S549F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C124(3.18)  LDD3412  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 RT-112 C124(2.05)  LDD2578  [1]
 LDCM0023  KB03 RT-112 C124(3.29)  LDD2995  [1]
 LDCM0024  KB05 RT-112 C124(3.18)  LDD3412  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840