Details of the Target
General Information of Target
| Target ID | LDTP06202 | |||||
|---|---|---|---|---|---|---|
| Target Name | Glycine N-methyltransferase (GNMT) |
|
||||
| Gene Name | GNMT | |||||
| Gene ID | 27232 | |||||
| Synonyms |
Glycine N-methyltransferase; EC 2.1.1.20 |
|||||
| 3D Structure | ||||||
| Sequence |
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQR
VLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMT LDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNY DHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSK FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Class I-like SAM-binding methyltransferase superfamily, Glycine N-methyltransferase family
|
|||||
| Subcellular location |
Cytoplasm
|
|||||
| Function |
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C58(1.32) | LDD3493 | [1] | |
Competitor(s) Related to This Target