Details of the Target

General Information of Target

Target ID LDTP06195
Target Name Sarcospan (SSPN)
Gene Name SSPN
Gene ID 8082
Synonyms
KRAG; Sarcospan; K-ras oncogene-associated protein; Kirsten-ras-associated protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGKNKQPRGQQRQGGPPAADAAGPDDMEPKKGTGAPKECGEEEPRTCCGCRFPLLLALLQ
LALGIAVTVVGFLMASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFS
MKLLYFLLSALGLTVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRD
VTDCTSVTGTFKLFLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQ
QKI
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.
Uniprot ID
Q14714
Ensemble ID
ENST00000242729.7
HGNC ID
HGNC:11322

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NALM6 SNV: p.A66T .
NCIH3122 SNV: p.C184F .
RL952 SNV: p.L105F; p.G132C .
SNGM Deletion: p.Q240SfsTer15 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264