General Information of Target

Target ID LDTP06151
Target Name Heat shock protein HSP 90-alpha A2 (HSP90AA2P)
Gene Name HSP90AA2P
Synonyms
HSP90AA2; HSPCAL3; Heat shock protein HSP 90-alpha A2; Heat shock 90 kDa protein 1 alpha-like 3; Heat shock protein HSP 90-alpha A2 pseudogene
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIW
YESLTDPSKLDSGKELHINLIPNKQDQTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVSFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGERM
GRGTKVILHLKEDQTEYLEEQRIKEIVKKHSQLIGYPITLFVEKECDKEVSDDETEEKED
KEEEKEKEEKESKDKPEIEDVGSDEEEEKKDGDKKKKKTKEKYIDQEELNKTKPIWTRNP
DDITNEEYGEFCKNLTNDWEDHLAVKHFSVEGQLEFRALLFVP
Target Bioclass
Other
Family
Heat shock protein 90 family
Subcellular location
Cytoplasm
Function Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.
Uniprot ID
Q14568
HGNC ID
HGNC:5256

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info 
D66(0.85); E331(0.84); D285(0.87); E288(0.83)  LDD2208  [1]
HHS-475
 Probe Info 
Y283(0.88)  LDD0264  [2]
HHS-465
 Probe Info 
Y283(10.00)  LDD2237  [3]
Ox-W18
 Probe Info 
N.A.  LDD2175  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y283(0.88)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y283(0.80)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y283(0.87)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y283(0.81)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y283(0.77)  LDD0268  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252