Details of the Target

General Information of Target

Target ID LDTP06149
Target Name Meiotic recombination protein DMC1/LIM15 homolog (DMC1)
Gene Name DMC1
Gene ID 11144
Synonyms
DMC1H; LIM15; Meiotic recombination protein DMC1/LIM15 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC
NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMA
ITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVD
HDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELA
ERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTR
ISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE
Target Bioclass
Other
Family
RecA family, DMC1 subfamily
Subcellular location
Nucleus
Function Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Uniprot ID
Q14565
Ensemble ID
ENST00000216024.7
HGNC ID
HGNC:2927

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P322S .
HDQP1 SNV: p.R230Ter .
IM95 SNV: p.E241K .
NCIH2172 SNV: p.S257L .
PF382 SNV: p.R252Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C60(2.70)  LDD2229  [1]

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048