Details of the Target

General Information of Target

Target ID LDTP06143
Target Name Hepatocyte nuclear factor 4-gamma (HNF4G)
Gene Name HNF4G
Gene ID 3174
Synonyms
NR2A2; Hepatocyte nuclear factor 4-gamma; HNF-4-gamma; Nuclear receptor subfamily 2 group A member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDK
RNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVS
SPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL
LLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACL
KAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITW
QMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMS
TLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR2 subfamily
Subcellular location
Nucleus
Function Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
Uniprot ID
Q14541
Ensemble ID
ENST00000354370.5
HGNC ID
HGNC:5026
ChEMBL ID
CHEMBL1961786

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C91(1.47)  LDD3333  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C239(1.54)  LDD2246  [1]
 LDCM0023  KB03 769-P C239(3.88)  LDD2663  [1]
 LDCM0024  KB05 MOLM-13 C91(1.47)  LDD3333  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840