Details of the Target

General Information of Target

Target ID LDTP06135
Target Name Hyaluronan-binding protein 2 (HABP2)
Gene Name HABP2
Gene ID 3026
Synonyms
HGFAL; PHBP; Hyaluronan-binding protein 2; EC 3.4.21.-; Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
TQVTKFLNWIKATIKSESGF
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration.
Uniprot ID
Q14520
Ensemble ID
ENST00000351270.4
HGNC ID
HGNC:4798

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.S399G .
CORL23 Insertion: p.V374GfsTer14 .
DU145 SNV: p.D488Y .
EFO21 SNV: p.I395M .
HCT15 SNV: p.Q542H .
HEC1 SNV: p.G495Ter .
HUPT3 SNV: p.Y195C .
ICC137 SNV: p.H353D DBIA    Probe Info 
KYSE180 SNV: p.C187S .
LS180 SNV: p.G239W .
NCIH196 Insertion: p.Q160PfsTer10 .
OVTOKO SNV: p.A214E .
RKO Deletion: p.V392del .
RPMI7951 SNV: p.H409Y .
SHP77 SNV: p.G458E .
SKMEL2 SNV: p.D299E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C424(2.27)  LDD3316  [1]
IA-alkyne
 Probe Info  		C424(7.21)  LDD1704  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell-activated C424(7.21)  LDD1704  [2]
 LDCM0023  KB03 A2780 C301(1.83)  LDD2671  [1]
 LDCM0024  KB05 MEL167 C424(2.27)  LDD3316  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hyaluronic Acid Small molecular drug DB08818

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.