General Information of Target

Target ID LDTP06102
Target Name Fibroleukin (FGL2)
Gene Name FGL2
Gene ID 10875
Synonyms
Fibroleukin; Fibrinogen-like protein 2; pT49
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLANWYWLSSAVLATYGFLVVANNETEEIKDERAKDVCPVRLESRGKCEEAGECPYQVS
LPPLTIQLPKQFSRIEEVFKEVQNLKEIVNSLKKSCQDCKLQADDNGDPGRNGLLLPSTG
APGEVGDNRVRELESEVNKLSSELKNAKEEINVLHGRLEKLNLVNMNNIENYVDSKVANL
TFVVNSLDGKCSKCPSQEQIQSRPVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNSSFEV
YCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMIL
RIDLEDFNGVELYALYDQFYVANEFLKYRLHVGNYNGTAGDALRFNKHYNHDLKFFTTPD
KDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQKYRGVRNGIFWGTWPGVSEAHPGG
YKSSFKEAKMMIRPKHFKP
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Secreted
Function May play a role in physiologic lymphocyte functions at mucosal sites.
TTD ID
T85835
Uniprot ID
Q14314
DrugMap ID
TTYBS89
Ensemble ID
ENST00000248598.6
HGNC ID
HGNC:3696

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C39(2.47)  LDD3366  [1]
N1
 Probe Info 
K145(0.00); K148(0.00)  LDD0245  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C39(2.84)  LDD2250  [1]
 LDCM0023  KB03 A101D C39(5.15)  LDD2667  [1]
 LDCM0024  KB05 NOMO-1 C39(2.47)  LDD3366  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.