Details of the Target

General Information of Target

Target ID LDTP06091
Target Name P-selectin glycoprotein ligand 1 (SELPLG)
Gene Name SELPLG
Gene ID 6404
Synonyms
P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD antigen CD162
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPP
EMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAME
IQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATE
AQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATE
AQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAA
SNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPT
EMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Membrane
Function
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.; (Microbial infection) Acts as a receptor for enterovirus 71.
TTD ID
T21865
Uniprot ID
Q14242
DrugMap ID
TTS5K8U
Ensemble ID
ENST00000228463.6
HGNC ID
HGNC:10722
ChEMBL ID
CHEMBL4183

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.V330L .
COLO800 SNV: p.Q245Ter .
DOTC24510 SNV: p.P34T .
HCT15 SNV: p.P176Q; p.K386N .
KYSE410 SNV: p.D50E .
MCC26 SNV: p.D371E .
MEWO SNV: p.P353L .
MOLT4 SNV: p.V288L .
NCIH146 SNV: p.S290F .
NCIH1793 SNV: p.S409C .
NCIH358 SNV: p.T194A .
PC14 SNV: p.E361Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C364(2.51)  LDD0304  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0024  KB05 T cell-activated C364(20.00)  LDD1710  [2]
 LDCM0131  RA190 MM1.R C364(2.51)  LDD0304  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sorting nexin-20 (SNX20) Sorting nexin family Q7Z614
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
P-selectin (SELP) Selectin/LECAM family P16109

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abgn-168 Antibody D02YIP
Ro-4905417 Antibody D0M7VE
Neihulizumab . D0I6IQ

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.