Details of the Target

General Information of Target

Target ID LDTP06044
Target Name Tripartite motif-containing protein 29 (TRIM29)
Gene Name TRIM29
Gene ID 23650
Synonyms
ATDC; Tripartite motif-containing protein 29; Ataxia telangiectasia group D-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTNGHGGEAAEGKSLGSAL
KPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGKRSPYAGLQLGAAKKPPVT
FAEKGELRKSIFSESRKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNK
QKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQ
TCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIK
SFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHED
KQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNFKDDLLNVC
MRHVEKMCKADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGG
VRTSYQPSSPGRFTKETTQKNFNNLYGTKGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFS
LKGYPSLMRSQSPKAQPQTWKSGKQTMLSHYRPFYVNKGNGIGSNEAP
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Uniprot ID
Q14134
Ensemble ID
ENST00000341846.10
HGNC ID
HGNC:17274

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HKGZCC SNV: p.Q362K DBIA    Probe Info 
IGR37 SNV: p.H397Y .
IGR39 SNV: p.H397Y .
KYM1 SNV: p.S538F .
LS180 Deletion: p.P391HfsTer19 .
MOLT4 SNV: p.R77Ter .
NALM6 Deletion: p.S162HfsTer97 .
NCIH1048 SNV: p.G11R .
NCIH2172 SNV: p.H46Q .
NCIH2286 SNV: p.S489Y .
OVCAR4 SNV: p.D87E .
SW1271 SNV: p.Q277L .
WM793 SNV: p.E326K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C225(1.31)  LDD3364  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
m-APA
 Probe Info  		H46(0.00); H448(0.00); H441(0.00)  LDD2231  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A431 C420(1.87)  LDD2258  [1]
 LDCM0023  KB03 A2780 C225(1.46)  LDD2671  [1]
 LDCM0024  KB05 NCI-N87 C225(1.31)  LDD3364  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Tripartite motif-containing protein 29 (TRIM29) . Q14134
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-3 (ACTN3) Alpha-actinin family Q08043
Segment polarity protein dishevelled homolog DVL-2 (DVL2) DSH family O14641
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Axin-1 (AXIN1) . O15169
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255