Details of the Target

General Information of Target

Target ID LDTP06041
Target Name Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C)
Gene Name PDE1C
Gene ID 5137
Synonyms
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Cam-PDE 1C; EC 3.1.4.17; Hcam3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKR
SGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR
LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGE
QQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLR
HFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
Subcellular location
Lysosome
Function
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
TTD ID
T92439
Uniprot ID
Q14123
DrugMap ID
TTW2HRK
Ensemble ID
ENST00000321453.12
HGNC ID
HGNC:8776
ChEMBL ID
CHEMBL4619

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.D167N .
COLO678 SNV: p.V435M .
COLO792 Substitution: p.S592A .
ECC2 Substitution: p.S592A .
EFO27 SNV: p.D502G .
HEC1 SNV: p.Y76H .
HT115 SNV: p.K573N .
IM95 SNV: p.R330Q .
LN18 SNV: p.W706C .
LNCaP clone FGC SNV: p.G589V; p.G623Ter .
MDAMB453 SNV: p.A543T .
MELJUSO SNV: p.W384G .
MEWO SNV: p.D96N .
MV411 Substitution: p.S592A .
NCIH1993 SNV: p.G248V .
NCIH2122 SNV: p.S200G .
NCIH2172 SNV: p.A133S .
OV90 SNV: p.L31F .
PC9 SNV: p.E595D .
PEO1 Deletion: p.A478_G482del .
SHP77 SNV: p.S129R .
TE8 Insertion: p.Q634TfsTer30 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264