Details of the Target

General Information of Target

Target ID LDTP06033
Target Name Protein Tob2 (TOB2)
Gene Name TOB2
Gene ID 10766
Synonyms
KIAA1663; TOB4; TROB2; Protein Tob2; Protein Tob4; Transducer of erbB-2 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHI
GEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVLYLDDSEGC
GAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQSPSPTFIPRSAQPITFTTAS
FAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPRMARSPTNSLLKHKSLSLSMHSL
NFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPFGGSGAGTCNSSSFD
MAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPSQQFQPVVLAN
Target Bioclass
Other
Family
BTG family
Subcellular location
Cytoplasm
Function Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Uniprot ID
Q14106
Ensemble ID
ENST00000327492.4
HGNC ID
HGNC:11980

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.T293I .
CHL1 SNV: p.G306E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C120(20.00)  LDD2227  [1]
DBIA
 Probe Info  		C120(1.83)  LDD1492  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C120(20.00)  LDD2227  [1]
 LDCM0022  KB02 HEK-293T C120(1.83)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C120(1.17)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C120(1.05)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 7 (CNOT7) CAF1 family Q9UIV1
CCR4-NOT transcription complex subunit 8 (CNOT8) CAF1 family Q9UFF9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Polyadenylate-binding protein 1 (PABPC1) Polyadenylate-binding protein type-1 family P11940

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402