Details of the Target

General Information of Target

Target ID LDTP06031
Target Name Ras-related protein Rab-33A (RAB33A)
Gene Name RAB33A
Gene ID 9363
Synonyms
RABS10; Ras-related protein Rab-33A; Small GTP-binding protein S10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQPILGHGSLQPASAAGLASLELDSSLDQYVQIRIFKIIVIGDSNVGKTCLTFRFCGGT
FPDKTEATIGVDFREKTVEIEGEKIKVQVWDTAGQERFRKSMVEHYYRNVHAVVFVYDVT
KMTSFTNLKMWIQECNGHAVPPLVPKVLVGNKCDLREQIQVPSNLALKFADAHNMLLFET
SAKDPKESQNVESIFMCLACRLKAQKSLLYRDAERQQGKVQKLEFPQEANSKTSCPC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cell membrane
Uniprot ID
Q14088
Ensemble ID
ENST00000257017.5
HGNC ID
HGNC:9773

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C57(2.91); C135(1.55)  LDD3332  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C57(0.00); C135(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C57(0.00); C135(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 A-375 C57(2.66)  LDD2255  [1]
 LDCM0023  KB03 A-375 C57(3.71)  LDD2672  [1]
 LDCM0024  KB05 MKN45 C57(2.91); C135(1.55)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Autophagy-related protein 16-1 (ATG16L1) WD repeat ATG16 family Q676U5
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Proteasome inhibitor PI31 subunit (PSMF1) Proteasome inhibitor PI31 family Q92530
LRP2-binding protein (LRP2BP) . Q9P2M1
Protein RUFY3 (RUFY3) . Q7L099

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853