Details of the Target

General Information of Target

Target ID LDTP06008
Target Name Calcyphosin (CAPS)
Gene Name CAPS
Gene ID 828
Synonyms
Calcyphosin; Calcyphosine
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQCHRDLALSQALWGWQLSKQSGWAHPSLPHSPLPSTVHSCSWAPPHLQRHLPLATVSPG
TTQLTQGPAGRTLGQTQASCPEPRPSMDAVDATMEKLRAQCLSRGASGIQGLARFFRQLD
RDGSRSLDADEFRQGLAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEFLRALRPPMSQAR
EAVIAAAFAKLDRSGDGVVTVDDLRGVYSGRAHPKVRSGEWTEDEVLRRFLDNFDSSEKD
GQVTLAEFQDYYSGVSASMNTDEEFVAMMTSAWQL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Calcium-binding protein. May play a role in cellular signaling events (Potential).
Uniprot ID
Q13938
Ensemble ID
ENST00000588776.8
HGNC ID
HGNC:1487

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y208(24.69)  LDD3495  [1]
DBIA
 Probe Info  		C66(1.90)  LDD3321  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-375 C66(1.11)  LDD2255  [2]
 LDCM0023  KB03 A101D C66(0.73)  LDD2667  [2]
 LDCM0024  KB05 SH4 C66(1.90)  LDD3321  [2]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264