Details of the Target

General Information of Target

Target ID LDTP06007
Target Name Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)
Gene Name CACNA1C
Gene ID 775
Synonyms
CACH2; CACN2; CACNL1A1; CCHL1A1; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAAR
QAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISI
VEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIA
YGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFR
VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYN
QEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI
TMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD
FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVA
GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLT
IASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGI
LETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFL
FIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG
GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR
TASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNP
ETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDT
IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF
TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVL
RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSD
SSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPEL
LYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNC
ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH
YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVIL
SETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFR
VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTE
INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA
VFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRI
KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRI
KTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFK
KRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASE
DDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDST
FTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLS
SNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETY
EVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRA
SFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPA
TPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLM
VPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESA
ADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSS
L
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1C subfamily
Subcellular location
Cell membrane
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).; (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues.
TTD ID
T51115
Uniprot ID
Q13936
DrugMap ID
TTZIFHC
Ensemble ID
ENST00000344100.7
HGNC ID
HGNC:1390
ChEMBL ID
CHEMBL1940

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		D1728(0.00); E1724(0.00); E1725(0.00); E1726(0.00)  LDD0236  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) Calcium channel beta subunit family P54284
Calcium-binding protein 1 (CABP1) . Q9NZU7
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-1 (ACTN1) Alpha-actinin family P12814
PRKCA-binding protein (PICK1) . Q9NRD5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 38 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amiodarone Small molecular drug DB01118
Amlodipine Small molecular drug DB00381
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Cinnarizine Small molecular drug DB00568
Clevidipine Small molecular drug DB04920
Diltiazem Small molecular drug DB00343
Dronedarone Small molecular drug DB04855
Drotaverine Small molecular drug DB06751
Enflurane Small molecular drug DB00228
Ergocalciferol Small molecular drug DB00153
Ethanol Small molecular drug DB00898
Felodipine Small molecular drug DB01023
Ibutilide Small molecular drug DB00308
Isavuconazole Small molecular drug DB11633
Isradipine Small molecular drug DB00270
Levamlodipine Small molecular drug DB09237
Levomenthol Small molecular drug DB00825
Manidipine Small molecular drug DB09238
Miconazole Small molecular drug DB01110
Nicardipine Small molecular drug DB00622
Nifedipine Small molecular drug DB01115
Nilvadipine Small molecular drug DB06712
Nimodipine Small molecular drug DB00393
Nisoldipine Small molecular drug DB00401
Nitrendipine Small molecular drug DB01054
Phenytoin Small molecular drug DB00252
Propiverine Small molecular drug DB12278
Ranolazine Small molecular drug DB00243
Rauwolfia Serpentina Root Small molecular drug D0U7GP
Spironolactone Small molecular drug DB00421
Topiramate Small molecular drug DB00273
Trimebutine Small molecular drug DB09089
Verapamil Small molecular drug DB00661
Bioallethrin . DB13746
Butamben . DB11148
Calcium Citrate . DB11093
Fish Oil . DB13961
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Arc029 Small molecular drug D06GRK
Investigative
Click To Hide/Show 19 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(-)-(R)-efonidipine Small molecular drug D0R6PX
(-)-(S)-bayk8644 Small molecular drug D02RIH
Cilnidipine Small molecular drug DB09232
Corynantheine Small molecular drug D09CKI
Cpu-228 Small molecular drug D09YTH
Cv-4093 Small molecular drug D0I9VY
Fpl64176 Small molecular drug D06XTT
Mebudipine Small molecular drug D04UDT
Mibefradil Small molecular drug DB01388
Pd-32577 Small molecular drug D08RJC
Sz(+)-(S)-202-791 Small molecular drug D0U7BI
[3h](+)-cis-diltiazem Small molecular drug D04ALU
[3h](+)-isradipine Small molecular drug D0S3YP
[3h](-)Devapamil Small molecular drug D03UJT
Aranidipine . DB09229
Barnidipine . DB09227
Benidipine . DB09231
Calcium . DB01373
Efonidipine . DB09235
Discontinued
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cgs-27830 Small molecular drug D00JMZ
Niguldipine Small molecular drug D05IML
R-56865 Small molecular drug D08MJX
Snap-5089 Small molecular drug D06HRY
Th-9229 . D0QQ7N

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.