Details of the Target

General Information of Target

Target ID LDTP05876
Target Name Limbic system-associated membrane protein (LSAMP)
Gene Name LSAMP
Gene ID 4045
Synonyms
IGLON3; LAMP; Limbic system-associated membrane protein; LSAMP; IgLON family member 3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVRRVQPDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNS
KVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPK
TSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEE
YLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCE
ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTN
ASLVLFRPGSVRGINGSISLAVPLWLLAASLLCLLSKC
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, IgLON family
Subcellular location
Cell membrane
Function
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection.
Uniprot ID
Q13449
Ensemble ID
ENST00000490035.7
HGNC ID
HGNC:6705

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0165  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 21 (MED21) Mediator complex subunit 21 family Q13503
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ETS domain-containing protein Elk-3 (ELK3) ETS family P41970
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuronal growth regulator 1 (NEGR1) IgLON family Q7Z3B1
Neurotrimin (NTM) IgLON family Q9P121
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DAP3-binding cell death enhancer 1 (DELE1) DELE1 family Q14154
Centromere protein V (CENPV) Gfa family Q7Z7K6
Histone H3.3C (H3-5) Histone H3 family Q6NXT2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Centromere protein R (ITGB3BP) . Q13352
Endosialin (CD248) . Q9HCU0
Leucine-rich repeat-containing protein 61 (LRRC61) . Q9BV99

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060