Details of the Target

General Information of Target

Target ID LDTP05860
Target Name Mesothelin (MSLN)
Gene Name MSLN
Gene ID 10232
Synonyms
MPF; Mesothelin; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor; MPF; Mesothelin, cleaved form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS
LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL
DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA
DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW
SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT
ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY
PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVA
TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ
LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL
PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS
MQEALSGTPCLLGPGPVLTVLALLLASTLA
Target Type
Clinical trial
Target Bioclass
Other
Family
Mesothelin family
Subcellular location
Secreted; Lipid-anchor, GPI-anchor; Cell membrane
Function Membrane-anchored forms may play a role in cellular adhesion.; Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
TTD ID
T87108
Uniprot ID
Q13421
DrugMap ID
TT4RXME
Ensemble ID
ENST00000382862.7
HGNC ID
HGNC:7371
ChEMBL ID
CHEMBL3712878

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K306(1.74); K307(1.74); K559(2.61); K299(3.10)  LDD3494  [1]
DBIA
 Probe Info  		C190(1.42)  LDD3360  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0022  KB02 A-549 C190(1.37); C211(0.93)  LDD2260  [2]
 LDCM0023  KB03 A2780 C190(1.49)  LDD2671  [2]
 LDCM0024  KB05 NCI-H3122 C190(1.42)  LDD3360  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid protein-binding protein 2 (APPBP2) . Q92624

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Morab-009 Antibody D0R6MJ
Anti-mesothelin Car Transduced Pbl CAR T Cell Therapy D00YXG
Anti-mesothelin Car-t Cells CAR T Cell Therapy D0BE6M
Car-t Cells Targeting Mesothelin CAR T Cell Therapy D0KC2S
Tc-210 TCR-T cell therapy DX6O9V
Crs-207 Vaccine D02WSB
Hpn536 . D0HW1L
Phase 1
Click To Hide/Show 19 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rg7882 Antibody D0V7QW
Anti-meso-car T Cells CAR T Cell Therapy D0CA3M
Anti-meso-car Vector Transduced T Cells CAR T Cell Therapy D0G4GY
Anti-mesothelin Car T Cells CAR T Cell Therapy D0PT5D
Ata2271 CAR T Cell Therapy DF9S1L
Autologous T Cells Transfected With Chimeric Anti-mesothelin Immunoreceptor Ss1 CAR T Cell Therapy D0EB0Y
Car-t Cells Targeting Mesothelin CAR T Cell Therapy D09YXN
Car-t Cells Targeting Mesothelin CAR T Cell Therapy D0L7OJ
Cart-meso Cells CAR T Cell Therapy D0P2GA
Hu-cart Meso Cells CAR T Cell Therapy D07YPB
Hucart-meso Cells CAR T Cell Therapy D0ZF9J
Icasp9m28z T Cell CAR T Cell Therapy D0S9FI
Meso-cart CAR T Cell Therapy D0D2LE
Mesothelin-targeted T Cells CAR T Cell Therapy D0O2XK
Cart-meso-19 T Cells CAR T Cell Therapy (Dual specific) D0V5DD
Cartmeso/19 CAR T Cell Therapy (Dual specific) D0MD8S
Mcy-m11 CAR-PBMC Cell therapy D8EIB7
227th-labelled Msln-ttc Radiopharmaceutical therapy DJ25DI
Bay 94-9343 . D0P5MG
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ata3271 CAR T Cell Therapy D8AI0N
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amatuximab . DB12845
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ss1(Dsfv)-pe38 Antibody D09YUK

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.