Details of the Target

General Information of Target

Target ID LDTP05840
Target Name Microfibrillar-associated protein 5 (MFAP5)
Gene Name MFAP5
Gene ID 8076
Synonyms
MAGP2; Microfibrillar-associated protein 5; MFAP-5; MP25; Microfibril-associated glycoprotein 2; MAGP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLLGPKVLLFLAAFIITSDWIPLGVNSQRGDDVTQATPETFTEDPNLVNDPATDETVLA
VLADIAPSTDDLASLSEKNTTAECWDEKFTCTRLYSVHRPVKQCIHQLCFTSLRRMYIVN
KEICSRLVCKEHEAMKDELCRQMAGLPPRRLRRSNYFRLPPCENVDLQRPNGL
Target Bioclass
Other
Family
MFAP family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils.
Uniprot ID
Q13361
Ensemble ID
ENST00000359478.7
HGNC ID
HGNC:29673

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.L48P .
CAL51 SNV: p.P6H .
JURKAT SNV: p.A37V .
NCIH1944 SNV: p.P148H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C140(2.18)  LDD3383  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Caov-3 C140(1.82)  LDD2295  [1]
 LDCM0023  KB03 Caov-3 C140(1.80)  LDD2712  [1]
 LDCM0024  KB05 OVCAR-5 C140(2.18)  LDD3383  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840