Details of the Target

General Information of Target

Target ID LDTP05818
Target Name Uracil nucleotide/cysteinyl leukotriene receptor (GPR17)
Gene Name GPR17
Gene ID 2840
Synonyms
Uracil nucleotide/cysteinyl leukotriene receptor; UDP/CysLT receptor; G-protein coupled receptor 17; P2Y-like receptor; R12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENM
LFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHF
SGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLAC
AFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCY
LLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQ
RILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESS
LSAKSEL
Target Type
Literature-reported
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
TTD ID
T33902
Uniprot ID
Q13304
DrugMap ID
TTMPART
Ensemble ID
ENST00000272644.7
HGNC ID
HGNC:4471
ChEMBL ID
CHEMBL1075162

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C297(1.22)  LDD2136  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C297(1.22)  LDD2136  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C297(0.98)  LDD2140  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Asn02563583 Small molecular drug D0KI5P
Asn04421891 Small molecular drug D00DPX
Asn04450772 Small molecular drug D07ZGV
Asn04885796 Small molecular drug D0Z2TV
Asn06917370 Small molecular drug D0J4RI
Galactose-uridine-5'-diphosphate Small molecular drug DB03501
Ltc4 Small molecular drug D0EW6H
Ltd4 Small molecular drug D03YBH
Lte4 Small molecular drug D0C0KJ
Udp-glucose Small molecular drug D07MIE
Uridine Diphosphate Glucose Small molecular drug DB01861
Uridine-5'-diphosphate Small molecular drug DB03435

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.