Details of the Target

General Information of Target

Target ID LDTP05810
Target Name Semaphorin-3F (SEMA3F)
Gene Name SEMA3F
Gene ID 6405
Synonyms
Semaphorin-3F; Sema III/F; Semaphorin IV; Sema IV
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL
LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR
LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA
PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ
TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYARIGRIC
LNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFT
SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS
MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEV
LFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGV
THLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRG
FNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTE
QGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGA
GPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRH
HPPDT
Target Bioclass
Immunoglobulin
Family
Semaphorin family
Subcellular location
Secreted
Function May play a role in cell motility and cell adhesion.
Uniprot ID
Q13275
Ensemble ID
ENST00000002829.8
HGNC ID
HGNC:10728

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.E216K .
HEC1 SNV: p.G43C .
HEC1B SNV: p.G43C .
KYSE30 SNV: p.R599C .
LS123 SNV: p.N593K .
MEWO SNV: p.P327S .
MOLT4 SNV: p.R590W .
P31FUJ SNV: p.M507I .
SW1271 SNV: p.S250Y .
TFK1 SNV: p.E192K .
UMUC3 SNV: p.G172V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K239(1.50); K581(3.30); K62(3.35)  LDD3494  [1]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888