Details of the Target
General Information of Target
| Target ID | LDTP05798 | |||||
|---|---|---|---|---|---|---|
| Target Name | Src-like-adapter (SLA) | |||||
| Gene Name | SLA | |||||
| Gene ID | 6503 | |||||
| Synonyms |
SLAP; SLAP1; Src-like-adapter; Src-like-adapter protein 1; SLAP-1; hSLAP |
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| 3D Structure | ||||||
| Sequence |
MGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWK
AISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFY SLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQST AAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLT SEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm
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| Function |
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
 |
C93(2.47) | LDD2412 | [1] | |
Competitor(s) Related to This Target