Details of the Target

General Information of Target

Target ID LDTP05787
Target Name Semaphorin-3B (SEMA3B)
Gene Name SEMA3B
Gene ID 7869
Synonyms
SEMA5; SEMAA; Semaphorin-3B; Sema A(V); Semaphorin-V; Sema V
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV
DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL
HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL
VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD
KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG
DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEG
PMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL
FLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELH
VFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA
CTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQAR
VEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSL
HVLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLP
LESRRKGRNRRTHAPEPRAERGPRSATHW
Target Bioclass
Immunoglobulin
Family
Semaphorin family
Subcellular location
Secreted
Function Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Uniprot ID
Q13214
Ensemble ID
ENST00000433753.4
HGNC ID
HGNC:10724

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.N271D .
CAKI1 SNV: p.P232Q .
Ishikawa (Heraklio) 02 ER SNV: p.G132D; p.V273L DBIA    Probe Info 
JHH1 Deletion: p.L322SfsTer19 DBIA    Probe Info 
JURKAT SNV: p.F225C .
KU1919 SNV: p.S367P DBIA    Probe Info 
MOLT4 SNV: p.Y324H .
NCIH1155 SNV: p.R348C DBIA    Probe Info 
RL952 SNV: p.I242F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C516(1.41)  LDD1702  [1]
DBIA
 Probe Info  		C534(1.05); C541(1.05)  LDD0078  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C534(1.05); C541(1.05)  LDD0078  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C516(1.41)  LDD1702  [1]
 LDCM0022  KB02 22RV1 C516(0.92)  LDD2243  [4]
 LDCM0023  KB03 786-O C516(1.66)  LDD2664  [4]
 LDCM0024  KB05 G361 C516(1.56)  LDD3311  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Heat shock factor 2-binding protein (HSF2BP) . O75031
Keratinocyte proline-rich protein (KPRP) . Q5T749
PRKCA-binding protein (PICK1) . Q9NRD5
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840