Details of the Target

General Information of Target

Target ID LDTP05745
Target Name Lymphocyte cytosolic protein 2 (LCP2)
Gene Name LCP2
Gene ID 3937
Synonyms
Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKL
RVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQ
DGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSG
KTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTK
PPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPL
PGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHM
PGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNE
EWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKES
QVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Involved in T-cell antigen receptor mediated signaling.
Uniprot ID
Q13094
Ensemble ID
ENST00000046794.10
HGNC ID
HGNC:6529

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K56(0.88)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 6 (ELOVL6) ELO family Q9H5J4
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) STE Ser/Thr protein kinase family Q8IVH8
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein kinase ITK/TSK (ITK) Tyr protein kinase family Q08881
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
T-cell differentiation antigen CD6 (CD6) . P30203
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Signal transducing adapter molecule 1 (STAM) STAM family Q92783
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Cytoplasmic protein NCK2 (NCK2) . O43639
FYN-binding protein 1 (FYB1) . O15117
Proto-oncogene vav (VAV1) . P15498
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853