Details of the Target
General Information of Target
| Target ID | LDTP05585 | |||||
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| Target Name | Acyl-coenzyme A synthetase ACSM2A, mitochondrial (ACSM2A) | |||||
| Gene Name | ACSM2A | |||||
| Gene ID | 123876 | |||||
| Synonyms |
ACSM2; MACS2; Acyl-coenzyme A synthetase ACSM2A, mitochondrial; EC 6.2.1.2; Acyl-CoA synthetase medium-chain family member 2A; Benzoate--CoA ligase; EC 6.2.1.25; Butyrate--CoA ligase 2A; Butyryl-coenzyme A synthetase 2A; Middle-chain acyl-CoA synthetase 2A
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| 3D Structure | ||||||
| Sequence |
MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKA
GKRLPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWW LVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIK LLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGL KAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDPLVILKTL SSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIRES YGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPI GIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVEN ALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKELQQHVKSVTAPYKY PRKIEFVLNLPKTVTGKIQRAKLRDKEWKMSGKARAQ |
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| Target Bioclass |
Enzyme
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| Family |
ATP-dependent AMP-binding enzyme family
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| Subcellular location |
Mitochondrion
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| Function |
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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C101(0.00); C188(0.00); C174(0.00) | LDD0241 | [1] | |